⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL396350 | 1.00 | — | — | |
| Bromide SCHEMBL1397996 | 0.98 | HRH4 (0.40) | — | |
| Bromide SCHEMBL4608777 | 0.98 | HRH4 (0.40) | — | |
| Hydrochloric Acid SCHEMBL630213 | 0.98 | HRH4 (0.43) | — | |
| Hydrochloric Acid SCHEMBL4609656 | 0.98 | HRH4 (0.43) | — | |
| Hydrochloric Acid SCHEMBL9700185 | 0.98 | HRH4 (0.43) | — | |
| Hydrochloric Acid SCHEMBL7111958 | 0.98 | HRH4 (0.43) | — | |
| SCHEMBL14900011 | 0.84 | DPP4 (0.35) | — | |
| SCHEMBL19187383 | 0.84 | DPP4 (0.35) | — | |
| Choline SCHEMBL27844516 | 0.84 | MEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569481-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8512675-B2 | N and/or Nα derivatized, metal and organic protected L-histidine for coupling to biomolecules for highly efficient labeling with [M(OH2)3 (CO)3]+ by fac coordination | MALLINCKRODT LLC (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | KOESTER HUBERT | 2011-05-19 | — | — | US | disclosed |
| US-20100298168-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-11-25 | — | — | US | disclosed |
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |
| US-7547523-B2 | Histamine receptor | SCHERING CORPORATION (US) | 2009-06-16 | — | — | US | disclosed |
| US-20070117155-A1 | HISTAMINE RECEPTOR | SCHERING CORPORATION | 2007-05-24 | — | — | US | disclosed |
| US-20070077195-A1 | \"N and/or nalpha derivatized, metal and organic protected l-histidine for coupling to biomolecules for highly efficient labeling with [m(oh2)3 (co)3]+ by fac coordination\ | UNIVERSITY OF ZURICH (CH) | 2007-04-05 | — | — | US | disclosed |
| US-7166705-B2 | Histamine receptor antibody | SCHERING CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050090527-A1 | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis | SCHERING CORPORATION | 2005-04-28 | — | — | US | disclosed |
| US-20050074768-A1 | Histamine receptor | MERCK SHARP & DOHME CORP. | 2005-04-07 | — | — | US | disclosed |
| WO-2004066960-A2 | COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS | SCHERING CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |
| US-6613533-B2 | Polypeptide; for use in the treatment of inflammation, asthma, allergy, dermatitis, stroke, myocardial infection, migraine, arthritis, multiple sclerosis, inflammatory bowel disease and psoriasis | SCHERING CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20020098539-A1 | Histamine receptor | BEHAN JIANG X (US) | 2002-07-25 | — | — | US | disclosed |
| US-6204017-B1 | AMINO ACID SEQUENCE; RECOMBINANT PRODUCTION; DRUG SCREENING FOR ANTAGONISTS AND AGONISTS; TREATMENT OF ASTHMA, ALLERGIES, CHRONIC OBSTRUCTIVE PULMONARY DISEASE; ANTIARTHRITIC AGENTS; ANTIINFLAMMATORY AGENTS; ANTIBODIES; PROBES; PRIMERS | SCHERING CORPORATION | 2001-03-20 | — | — | US | disclosed |
| US-5162541-A | Using palladium containing catalysts and a hydrogen donor | SCHERING CORPORATION (US) | 1992-11-10 | — | — | US | disclosed |