Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.53 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.53 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.53 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.53 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.53 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.53 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.53 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.53 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.53 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.53 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.53 |
| ▸ | NDUFS2 | O75306 | 1/20 | 0.53 |
| ▸ | NDUFS6 | O75380 | 1/20 | 0.53 |
| ▸ | NDUFB1 | O75438 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009150 | 1.00 | MAPT (0.58) | MAPTNLRP3KMT2AMEN1RECQL | |
| SCHEMBL7372285 | 0.81 | MAPT (0.86) | MAPTNLRP3KMT2AMEN1RECQL | |
| SCHEMBL3867760 | 0.79 | MCHR1 (0.62) | MAPTKMT2AMEN1CYP1A2ALDH1A1 | |
| SCHEMBL19414167 | 0.79 | MAPT (0.62) | MAPTKMT2AMEN1RECQLLMNA | |
| SCHEMBL23291261 | 0.78 | CYP1A2 (0.56) | MAPTKMT2AMEN1CYP1A2BCHE | |
| SCHEMBL4375129 | 0.76 | MAPT (0.78) | MAPTNLRP3RECQLBCHEACHE | |
| SCHEMBL11569149 | 0.76 | PPARA (0.67) | MAPTNLRP3KMT2AMEN1RECQL | |
| SCHEMBL11569152 | 0.76 | PPARA (0.67) | MAPTNLRP3KMT2AMEN1RECQL | |
| SCHEMBL25311354 | 0.76 | APP (0.65) | MAPTLMNANDUFS8COXFA4NDUFAB1 | |
| SCHEMBL29472500 | 0.76 | APP (0.65) | MAPTLMNANDUFS8COXFA4NDUFAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558567-B1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-06-24 | — | — | EP | claimed |
| US-7351719-B2 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-04-01 | — | — | US | claimed |
| US-20040152742-A1 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-08-05 | — | — | US | claimed |
| EP-1558567-B1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-06-24 | — | — | EP | disclosed |
| US-7351719-B2 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-04-01 | — | — | US | disclosed |
| EP-1558567-A1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | disclosed |
| US-20040152742-A1 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-08-05 | — | — | US | disclosed |
| WO-2004039764-A1 | NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152742-A1 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds | MCHR2, MCHR1, NPY1R | MAPT 4346/4885NLRP3 3576/4885KMT2A 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.