Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010698 | 1.00 | EPHX2 (0.65) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL4005679 | 0.91 | EPHX2 (0.76) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL610201 | 0.89 | TDP1 (0.67) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL610202 | 0.89 | TDP1 (0.67) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL611212 | 0.89 | TDP1 (0.67) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL612184 | 0.89 | TDP1 (0.67) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL4002852 | 0.87 | EPHX2 (0.60) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL4002862 | 0.87 | EPHX2 (0.60) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL611344 | 0.85 | KMT2A (0.78) | EPHX2KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL612912 | 0.85 | KMT2A (0.78) | EPHX2KMT2AALDH1A1MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |