Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011236 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL563302 | 0.85 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL563303 | 0.85 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL3910873 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL3910881 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10183507 | 0.79 | ADORA2A (0.43) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL562706 | 0.78 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL562703 | 0.78 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL561895 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL561896 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044074-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007150025-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |