Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.37 |
| ▸ | ME1 | P48163 | 1/20 | 0.37 |
| ▸ | ME3 | Q16798 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962981 | 0.92 | TAAR1 (0.39) | TAAR1GPBAR1MAPTSMN1; SMN2HTT | |
| SCHEMBL4013090 | 0.92 | TAAR1 (0.39) | TAAR1GPBAR1MAPTSMN1; SMN2HTT | |
| SCHEMBL4009380 | 0.87 | HPGD (0.39) | TAAR1MAPTSMN1; SMN2HTTPTGDR2 | |
| SCHEMBL13963134 | 0.85 | HPGD (0.34) | TAAR1GPBAR1MAPTSMN1; SMN2HTT | |
| SCHEMBL13963129 | 0.85 | TAAR1 (0.36) | TAAR1GPBAR1MAPTSMN1; SMN2HTT | |
| SCHEMBL4009901 | 0.85 | CHRM1 (0.38) | TAAR1PTGDR2ME2ME1ME3 | |
| SCHEMBL4012393 | 0.83 | TAAR1 (0.34) | TAAR1GPBAR1MAPTSMN1; SMN2HTT | |
| SCHEMBL4005110 | 0.83 | HPGD (0.43) | TAAR1MAPTSMN1; SMN2HTTPTGDR2 | |
| SCHEMBL13962552 | 0.83 | PTGDR2 (0.36) | TAAR1GPBAR1PTGDR2ME2ME1 | |
| SCHEMBL13963125 | 0.83 | TAAR1 (0.35) | TAAR1GPBAR1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |