Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 19/20 | 0.75 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124253 | 0.86 | NR1H2 (0.68) | NR1H2NR1H3USP2TP53MAPK1 | |
| SCHEMBL4020682 | 0.86 | NR1H2 (1.00) | NR1H2NR1H3 | |
| SCHEMBL1124932 | 0.84 | NR1H2 (0.68) | NR1H2NR1H3USP2TP53MAPK1 | |
| SCHEMBL1124177 | 0.84 | USP2 (0.57) | NR1H2NR1H3USP2TP53MAPK1 | |
| SCHEMBL1124699 | 0.84 | NR1H2 (0.67) | NR1H2NR1H3USP2TP53MAPK1 | |
| SCHEMBL4012657 | 0.83 | NR1H2 (0.84) | NR1H2NR1H3 | |
| SCHEMBL4010815 | 0.78 | NR1H2 (0.65) | NR1H2NR1H3 | |
| SCHEMBL4013226 | 0.78 | NR1H2 (0.73) | NR1H2NR1H3 | |
| SCHEMBL4010991 | 0.77 | NR1H2 (0.73) | NR1H2NR1H3 | |
| SCHEMBL4013328 | 0.76 | NR1H2 (0.72) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |