Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 18/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25073108 | 0.90 | AKR1C3 (0.58) | AKR1C3MEN1KMT2AAKR1C1HDAC6 | |
| SCHEMBL3280649 | 0.88 | AKR1C3 (0.76) | AKR1C3MEN1KMT2AAKR1C1 | |
| SCHEMBL3282209 | 0.88 | AKR1C3 (0.67) | AKR1C3MEN1KMT2AAKR1C1 | |
| SCHEMBL3282044 | 0.88 | AKR1C3 (0.73) | AKR1C3AKR1C1HDAC6 | |
| SCHEMBL3284957 | 0.88 | AKR1C3 (0.73) | AKR1C3AKR1C1 | |
| SCHEMBL3282023 | 0.87 | HDAC6 (0.71) | AKR1C3AKR1C1HDAC6 | |
| SCHEMBL3286988 | 0.86 | AKR1C3 (0.73) | AKR1C3MEN1KMT2AAKR1C1 | |
| SCHEMBL3282211 | 0.84 | AKR1C3 (0.77) | AKR1C3MEN1KMT2AAKR1C1 | |
| SCHEMBL3281251 | 0.84 | AKR1C3 (0.76) | AKR1C3AKR1C1 | |
| SCHEMBL4239496 | 0.83 | AKR1C3 (0.76) | AKR1C3MEN1KMT2AAKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |