Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 11/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | CDC7 | O00311 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | PAK4 | O96013 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | PRKX | P51817 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009506 | 0.92 | CDK7 (0.48) | CDK7FLT3CDC7FGFR1FGFR3 | |
| SCHEMBL4008460 | 0.85 | CDK7 (0.48) | CDK7FLT3CDC7FGFR1FGFR3 | |
| SCHEMBL4003421 | 0.83 | CDK7 (0.48) | CDK7FLT3CDC7FGFR1FGFR3 | |
| SCHEMBL4013301 | 0.83 | FLT3 (0.51) | FLT3MAP4K4CLK2CDK5MAP4K2 | |
| SCHEMBL4007934 | 0.82 | MAPT (0.61) | CDK7FLT3CDC7FGFR1FGFR3 | |
| SCHEMBL4013332 | 0.80 | GPR17 (0.40) | MAPK1GPR17P2RY2NTRK1 | |
| SCHEMBL4010904 | 0.79 | MAP2K4 (0.47) | FLT3MAP4K4CLK2MAP4K2DYRK1A | |
| SCHEMBL4014693 | 0.79 | NTRK1 (0.48) | FLT3DYRK1ANTRK3GPR17P2RY2 | |
| SCHEMBL4008083 | 0.79 | CDK7 (0.48) | CDK7FLT3CDC7FGFR1FGFR3 | |
| SCHEMBL16934639 | 0.78 | CDK7 (0.57) | CDK7FLT3CDC7FGFR1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | disclosed |
| US-20050059722-A1 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2005-03-17 | — | — | US | disclosed |
| US-6858638-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2005-02-22 | — | — | US | disclosed |
| US-20040106667-A1 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106667-A1 | Substituted indazoles, compositions containing them, method of production and use | ABL1, CDK3, CILK1 | CDK7 29/4885FLT3 58/4885CDC7 243/4885 |
| US-20050059722-A1 | Substituted indazoles, compositions containing them, method of production and use | ABL1, CDK3, CILK1 | CDK7 33/4885FLT3 75/4885CDC7 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.