Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013361 | 1.00 | HTR2A (0.52) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4020460 | 0.87 | CYP2D6 (0.64) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4020462 | 0.87 | CYP2D6 (0.64) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4015055 | 0.85 | KMT2A (0.61) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4016838 | 0.85 | KMT2A (0.61) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4916248 | 0.79 | CYP2D6 (0.47) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4014078 | 0.79 | HTR2A (0.51) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4014072 | 0.79 | HTR2A (0.51) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4019914 | 0.79 | HTR2A (0.53) | HTR2AKCNH2CYP2D6NFE2L2KMT2A | |
| SCHEMBL4022369 | 0.79 | HTR2A (0.53) | HTR2AKCNH2CYP2D6NFE2L2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280956-A1 | Heteroarylsulfonyl Stilbenes as 5-Ht2a Antagonists | GILLIGAN MYRA | 2008-11-13 | — | — | US | claimed |
| EP-1858852-B1 | HETEROARYLSULFONYL STILBENES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2009-07-01 | — | — | EP | disclosed |
| US-20080280956-A1 | Heteroarylsulfonyl Stilbenes as 5-Ht2a Antagonists | GILLIGAN MYRA | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280956-A1 | Heteroarylsulfonyl Stilbenes as 5-Ht2a Antagonists | HTR2A, HTR2B, HTR2C | HTR2A 1/4885KCNH2 1308/4885CYP2D6 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.