Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.62 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.62 |
| ▸ | RXRA | P19793 | 1/20 | 0.62 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013051 | 0.95 | NR1H2 (0.67) | NR1H2NR1H3RXRATAS2R14 | |
| SCHEMBL4012177 | 0.85 | NR1H2 (0.70) | NR1H2NR1H3 | |
| SCHEMBL4009726 | 0.82 | NR1H2 (0.73) | NR1H2NR1H3RXRA | |
| SCHEMBL4012467 | 0.82 | NR1H2 (0.86) | NR1H2NR1H3RXRA | |
| SCHEMBL4013937 | 0.81 | NR1H2 (0.74) | NR1H2NR1H3RXRA | |
| SCHEMBL4012845 | 0.80 | NR1H2 (0.69) | NR1H2NR1H3 | |
| SCHEMBL4011703 | 0.80 | NR1H2 (0.69) | NR1H2NR1H3RXRA | |
| SCHEMBL4017704 | 0.80 | NR1H2 (0.87) | NR1H2NR1H3RXRA | |
| SCHEMBL4013275 | 0.79 | NR1H2 (0.70) | NR1H2NR1H3RXRA | |
| SCHEMBL4012557 | 0.79 | NR1H2 (0.68) | NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |