Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 18/20 | 0.64 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381328 | 0.90 | CNR1 (0.78) | CNR1TACR2CNR2KCNH2SCN5A | |
| SCHEMBL4013404 | 0.87 | CNR1 (0.54) | CNR1TACR2CNR2KCNH2SCN5A | |
| SCHEMBL4013474 | 0.84 | CNR1 (0.54) | CNR1CNR2KCNH2SCN5ASCN2A | |
| SCHEMBL1379050 | 0.82 | CNR1 (0.66) | CNR1TACR2CNR2KCNH2SCN5A | |
| SCHEMBL1377491 | 0.82 | CNR1 (0.66) | CNR1TACR2CNR2HPGDS | |
| SCHEMBL2704083 | 0.79 | CNR1 (1.00) | CNR1TACR2CNR2 | |
| SCHEMBL1377601 | 0.79 | CNR1 (0.80) | CNR1TACR2CNR2 | |
| SCHEMBL1378633 | 0.79 | CNR1 (1.00) | CNR1TACR2CNR2 | |
| SCHEMBL2701908 | 0.79 | CNR1 (1.00) | CNR1TACR2CNR2 | |
| SCHEMBL1380465 | 0.78 | CNR1 (0.78) | CNR1TACR2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074096-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-01 | — | — | EP | claimed |
| WO-2008040651-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-10 | — | — | WO | claimed |