Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.67 |
| ▸ | TUBB | P07437 | 1/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.67 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.67 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.67 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.67 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.67 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.67 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.67 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.67 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.67 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.67 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 2/20 | 0.62 |
| ▸ | SGK1 | O00141 | 1/20 | 0.62 |
| ▸ | TEK | Q02763 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013531 | 1.00 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL4013034 | 0.83 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4013041 | 0.83 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL31061315 | 0.80 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6674608 | 0.80 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6674605 | 0.80 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL4178095 | 0.79 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL4178102 | 0.79 | CHEK1 (1.00) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6861577 | 0.78 | CHEK1 (0.69) | CHEK1CHEK2TUBB4ATUBBTUBA3C | |
| SCHEMBL6646612 | 0.78 | CHEK1 (0.69) | CHEK1CHEK2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085040-A1 | PROTEIN KINASE INHIBITORS | DCB-USA LLC (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090163494-A1 | PROTEIN KINASE INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163494-A1 | PROTEIN KINASE INHIBITORS | BRAF, MAP3K20, SELENOI | CHEK1 120/4885CHEK2 178/4885TUBB4A 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.