Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.45 |
| ▸ | CLK1 | P49759 | 8/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.45 |
| ▸ | CLK3 | P49761 | 3/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448323 | 0.85 | CLK1 (0.66) | MAPTALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL8022002 | 0.80 | MAPT (0.46) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL8032406 | 0.79 | DYRK1A (0.68) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL4154294 | 0.78 | DYRK1A (0.49) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL4016943 | 0.78 | DYRK1A (0.49) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL24718936 | 0.78 | DYRK1A (0.49) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL4012059 | 0.76 | MAPT (0.70) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL8036325 | 0.76 | DYRK1A (0.50) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL4012203 | 0.76 | DYRK1A (0.48) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL4016959 | 0.76 | DYRK1A (0.47) | MAPTALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |