Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12832029 | 0.92 | SMO (0.77) | SMOMAPTLMNATDP1RAB9A | |
| SCHEMBL402625 | 0.92 | SMO (0.60) | SMOMAPTLMNARAB9ANPC1 | |
| SCHEMBL400560 | 0.91 | SMO (0.61) | SMOMAPTRAB9ANPC1KCNQ3 | |
| SCHEMBL399798 | 0.91 | SMO (0.63) | SMOMAPTLMNATDP1RAB9A | |
| SCHEMBL404073 | 0.91 | SMO (0.59) | SMOMAPTLMNARAB9ANPC1 | |
| SCHEMBL10238332 | 0.89 | SMO (0.58) | SMOMAPTLMNARAB9ANPC1 | |
| SCHEMBL400145 | 0.88 | SMO (0.73) | SMOMAPTLMNARAB9ANPC1 | |
| SCHEMBL10238407 | 0.87 | SMO (0.56) | SMOALDH1A1 | |
| SCHEMBL399857 | 0.87 | MAPT (0.57) | SMOMAPTLMNARAB9ANPC1 | |
| SCHEMBL404013 | 0.87 | SMO (0.57) | SMOMAPTLMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-B1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH INC (US) | 2016-11-02 | — | — | EP | claimed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | claimed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | claimed |
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | claimed |
| US-9910050-B2 | Mutant smoothened and methods of using the same | GENENTECH, INC. (US) | 2018-03-06 | — | — | US | disclosed |
| EP-1957461-B1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH INC (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20160313354-A1 | MUTANT SMOOTHENED AND METHODS OF USING THE SAME | GENENTECH, INC. | 2016-10-27 | — | — | US | disclosed |
| EP-2625197-B1 | MUTANT SMOOTHENED AND METHODS OF USING THE SAME | GENENTECH INC (US) | 2016-06-29 | — | — | EP | disclosed |
| US-9321823-B2 | Mutant smoothened and methods of using the same | GENENTECH, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-9096686-B2 | E518A/K mutant smoothened and methods of using the same | GENENTECH, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-8481680-B2 | Mutant smoothened and methods of using the same | GENENTECH, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20120039893-A1 | MUTANT SMOOTHENED AND METHODS OF USING THE SAME | GENENTECH, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101610-B2 | Blocking signals; anticancer agents | GENENTECH, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | disclosed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | disclosed |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | GENENTECH INC. (US) | 2008-10-30 | — | — | US | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120039893-A1 | MUTANT SMOOTHENED AND METHODS OF USING THE SAME | SMO, SHH, GLI1 | SMO 1/4885MAPT 4069/4885LMNA 4475/4885 |
| US-20080269215-A1 | Bisamide Inhibitors of Hedgehog Signaling | SHH, GLI1, SMO | SMO 3/4885MAPT 2726/4885LMNA 3681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.