Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.69 |
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2484717 | 0.82 | ATR (1.00) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL3979058 | 0.81 | ATR (0.76) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL2509897 | 0.81 | ATR (1.00) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL19672786 | 0.81 | ATR (0.71) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL3054972 | 0.79 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL4006257 | 0.79 | ATR (0.74) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL2681744 | 0.78 | CDK1 (0.70) | ATRAURKACDK1CDK2AURKB | |
| SCHEMBL2513033 | 0.77 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL3469604 | 0.77 | ATR (0.76) | ATRPRKDCATMCDK1CDK2 | |
| SCHEMBL4436195 | 0.76 | ATR (0.67) | ATRPRKDCATMEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |