Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161023 | 0.78 | HRH3 (0.52) | HRH3KCNH2MAPK1HTTHSD17B10 | |
| SCHEMBL14000448 | 0.73 | HRH3 (0.65) | HRH3KCNH2HSD17B10 | |
| SCHEMBL3670242 | 0.73 | HRH3 (0.65) | HRH3KCNH2HSD17B10 | |
| SCHEMBL3670248 | 0.73 | HRH3 (0.65) | HRH3KCNH2HSD17B10 | |
| SCHEMBL3675661 | 0.72 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL3670278 | 0.72 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL3670282 | 0.72 | HRH3 (0.69) | HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL3724199 | 0.71 | HRH3 (0.68) | HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL3724197 | 0.71 | HRH3 (0.68) | HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL4944586 | 0.71 | HRH3 (0.68) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | disclosed |