Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.75 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.75 |
| ▸ | KDR | P35968 | 9/20 | 0.74 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.72 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.72 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.72 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.72 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.72 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.72 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.71 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.71 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933647 | 0.96 | PRKAA1 (0.71) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL3933120 | 0.92 | PDGFRB (0.80) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626038 | 0.91 | PDGFRB (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626040 | 0.91 | PDGFRB (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL13961195 | 0.91 | PRKAA1 (0.78) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL2116966 | 0.91 | PRKAA1 (0.78) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL31672446 | 0.91 | PRKAA1 (0.78) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL13960180 | 0.90 | PRKAA1 (0.80) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626727 | 0.89 | HDAC3 (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB | |
| SCHEMBL1626728 | 0.89 | HDAC3 (0.81) | PRKAA1PRKAA2KDRTLK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014941-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | SHENZEN CHIPSCREEN BIOSCIENCE, LTD. (CN) | 2009-01-29 | — | — | WO | disclosed |