Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | MC5R | P33032 | 3/20 | 0.46 |
| ▸ | MC1R | Q01726 | 3/20 | 0.46 |
| ▸ | MC3R | P41968 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015499 | 1.00 | MAPT (0.54) | MAPTHDAC1HDAC6CFTRTDP1 | |
| SCHEMBL4022321 | 0.83 | MAPT (0.71) | MAPTTDP1LMNACYP2D6CYP2C19 | |
| SCHEMBL4022324 | 0.83 | MAPT (0.71) | MAPTTDP1LMNACYP2D6CYP2C19 | |
| SCHEMBL12172749 | 0.83 | MAPT (0.71) | MAPTTDP1LMNACYP2D6CYP2C19 | |
| SCHEMBL4020838 | 0.82 | CYP1A2 (0.53) | TDP1LMNARECQLSMN1; SMN2CYP1A2 | |
| SCHEMBL4020831 | 0.82 | CYP1A2 (0.53) | TDP1LMNARECQLSMN1; SMN2CYP1A2 | |
| SCHEMBL25375484 | 0.79 | HDAC1 (0.55) | HDAC1HDAC6CFTRTDP1MC4R | |
| SCHEMBL15779266 | 0.78 | MAPT (0.63) | MAPTTDP1LMNAKDM4EMEN1 | |
| SCHEMBL15779268 | 0.78 | MAPT (0.63) | MAPTTDP1LMNAKDM4EMEN1 | |
| SCHEMBL4018479 | 0.77 | MAPT (0.57) | MAPTMC4RMC5RMC3RCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482379-B2 | Propenoyl hydrazides | GEORGIA TECH RESEARCH CORPORATION (US) | 2009-01-27 | — | — | US | disclosed |
| US-20050256058-A1 | Propenoyl hydrazides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256058-A1 | Propenoyl hydrazides | DNPEP, HPN, PREP | MAPT 3551/4885HDAC1 577/4885HDAC6 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.