Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365181 | 0.90 | NR1H2 (0.65) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL18379840 | 0.90 | ESR2 (0.53) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL29407557 | 0.89 | NR1H2 (0.69) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL1285596 | 0.89 | NR1H2 (0.69) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL12376466 | 0.89 | NR1H2 (0.69) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL22981583 | 0.88 | NR1H2 (0.67) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL1286143 | 0.88 | NR1H2 (0.67) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL29388691 | 0.88 | NR1H2 (0.67) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL29421745 | 0.88 | NR1H2 (0.67) | NR1H2ESR2MAPK1HDAC1TMEM97 | |
| SCHEMBL13274356 | 0.88 | NR1H2 (0.71) | NR1H2ESR2MAPK1HDAC1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |