Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.46 |
| ▸ | MTOR | P42345 | 16/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020766 | 0.84 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4166418 | 0.82 | PIK3CA (0.66) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4021162 | 0.81 | PIK3CA (0.46) | PIK3CAMTORPIK3CG | |
| SCHEMBL4019431 | 0.81 | PIK3CA (0.45) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4020613 | 0.79 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4020422 | 0.77 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4185149 | 0.73 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4191046 | 0.70 | CHKA (0.46) | PIK3CAMTORPIK3CG | |
| SCHEMBL4026081 | 0.70 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL4020168 | 0.70 | PIK3CA (0.69) | PIK3CAMTORPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009097490-A1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-08-06 | — | — | WO | claimed |