Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.83 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.83 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.83 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.83 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.83 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.83 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.83 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.83 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.83 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.83 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.83 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.81 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.81 |
| ▸ | KDR | P35968 | 10/20 | 0.80 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.79 |
| ▸ | CSF1R | P07333 | 3/20 | 0.76 |
| ▸ | PLK4 | O00444 | 2/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1625650 | 0.93 | PDGFRB (0.84) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625652 | 0.93 | PDGFRB (0.84) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625556 | 0.93 | PDGFRB (0.84) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4016628 | 0.93 | PDGFRB (0.84) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625555 | 0.93 | PDGFRB (0.84) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13960175 | 0.93 | PDGFRB (0.83) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3930220 | 0.92 | PDGFRB (0.82) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13960774 | 0.92 | PRKAA1 (0.83) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626040 | 0.91 | PDGFRB (0.81) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625529 | 0.91 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014941-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | SHENZEN CHIPSCREEN BIOSCIENCE, LTD. (CN) | 2009-01-29 | — | — | WO | disclosed |