Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.77 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 5/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019299 | 1.00 | CHEK1 (0.77) | CHEK1PRKAA1KDRPRKAA2PLK4 | |
| SCHEMBL4013804 | 0.93 | CHEK1 (0.70) | CHEK1PRKAA1KDRPRKAA2PLK4 | |
| SCHEMBL4013806 | 0.93 | CHEK1 (0.70) | CHEK1PRKAA1KDRPRKAA2PLK4 | |
| SCHEMBL4016918 | 0.87 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4016913 | 0.87 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4016416 | 0.86 | CHEK1 (0.82) | CHEK1PRKAA1KDRPRKAA2 | |
| SCHEMBL4016413 | 0.86 | CHEK1 (0.82) | CHEK1PRKAA1KDRPRKAA2 | |
| SCHEMBL4016660 | 0.85 | CHEK1 (0.84) | CHEK1 | |
| SCHEMBL4016657 | 0.85 | CHEK1 (0.84) | CHEK1 | |
| SCHEMBL4020905 | 0.84 | CHEK1 (0.70) | CHEK1PRKAA1KDRPRKAA2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085040-A1 | PROTEIN KINASE INHIBITORS | DCB-USA LLC (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090163494-A1 | PROTEIN KINASE INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163494-A1 | PROTEIN KINASE INHIBITORS | BRAF, MAP3K20, SELENOI | CHEK1 120/4885PRKAA1 288/4885KDR 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.