Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 4/20 | 0.54 |
| ▸ | PLK4 | O00444 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 12/20 | 0.39 |
| ▸ | GSK3B | P49841 | 7/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22054614 | 0.81 | PAK4 (0.53) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL4184328 | 0.79 | PLK4 (0.61) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL24996468 | 0.75 | PLK4 (0.63) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL22054231 | 0.75 | PLK4 (0.60) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL801864 | 0.75 | PAK4 (0.59) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL588674 | 0.75 | PAK4 (0.62) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL2242602 | 0.73 | JAK2 (0.37) | PAK4AURKAFGFR1JAK2JAK3 | |
| SCHEMBL22600946 | 0.72 | PAK4 (0.59) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL219046 | 0.72 | PAK4 (0.59) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL220647 | 0.71 | PAK4 (0.57) | PAK4PLK4MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013545-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | WO | disclosed |