Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 19/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016089 | 0.82 | CCR1 (0.42) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4016331 | 0.82 | CCR1 (0.44) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4306658 | 0.81 | CCR1 (0.42) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4018857 | 0.81 | CCR1 (0.47) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4555895 | 0.81 | CCR1 (0.44) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4017338 | 0.81 | CCR1 (0.46) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4017397 | 0.80 | CCR1 (0.45) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4014907 | 0.80 | CCR1 (0.45) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4015384 | 0.80 | CCR1 (0.41) | CCR1CYP2C19KCNH2 | |
| SCHEMBL4021722 | 0.80 | CCR1 (0.45) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |