Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 12/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399614 | 0.90 | AURKA (0.47) | AURKAAURKB | |
| SCHEMBL399206 | 0.90 | AURKA (0.40) | AURKAAURKBP2RX7CTSSCTSK | |
| SCHEMBL401151 | 0.85 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL403361 | 0.85 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL398924 | 0.85 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL3535817 | 0.80 | AURKA (0.51) | AURKAAURKB | |
| SCHEMBL3529733 | 0.79 | AURKA (0.40) | AURKAAURKBP2RX7 | |
| SCHEMBL3526082 | 0.79 | AURKA (0.40) | AURKAAURKBP2RX7 | |
| SCHEMBL401815 | 0.78 | AURKA (0.46) | AURKAAURKBP2RX7 | |
| Trifluoroacetic Acid SCHEMBL15225961 | 0.78 | AURKA (0.34) | AURKAAURKBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2017279-B1 | AMINOPYRIMIDINE DERIVATIVES HAVING AURORA-A-SELECTIVE INHIBITORY ACTIVITY | MSD KK (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-8101621-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | MSD K.K. (JP) | 2012-01-24 | — | — | US | disclosed |
| US-20090192174-A1 | Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-07-30 | — | — | US | disclosed |
| EP-2017279-A1 | NOVEL AMINOPYRIDINE DERIVATIVE HAVING AURORA-A-SELECTIVE INHIBITORY ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192174-A1 | Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action | RB1, AURKA, AURKC | AURKA 2/4885AURKB 4/4885P2RX7 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.