Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47003 | 0.83 | SLC34A2 (0.79) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL15420909 | 0.81 | SLC34A2 (0.57) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL40211 | 0.81 | SLC34A2 (0.57) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL15421437 | 0.81 | SLC34A2 (0.55) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL15421440 | 0.81 | SLC34A2 (0.55) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL40113 | 0.81 | SLC34A2 (0.68) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL18482989 | 0.81 | SLC34A2 (0.53) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL47063 | 0.81 | SLC34A2 (0.66) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL40155 | 0.80 | SLC34A2 (0.72) | SLC34A2ROCK2ROCK1PSEN1PSEN2 | |
| SCHEMBL15432551 | 0.80 | SLC34A2 (0.59) | SLC34A2BRAFSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |