⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052963 | 0.76 | — | — | |
| SCHEMBL2362410 | 0.76 | — | — | |
| SCHEMBL14845193 | 0.75 | TSHR (0.41) | — | |
| Hydrochloric Acid SCHEMBL27646724 | 0.74 | — | — | |
| SCHEMBL8637692 | 0.73 | — | — | |
| SCHEMBL169182 | 0.73 | — | — | |
| SCHEMBL1991500 | 0.73 | TSHR (0.38) | — | |
| SCHEMBL7789795 | 0.73 | — | — | |
| SCHEMBL3296338 | 0.71 | — | — | |
| SCHEMBL4247978 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023357-A2 | CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS | UNIVERSITY OF ROCHESTER (US) | 2009-02-19 | — | — | WO | claimed |
| CN-104650342-B | Highly branched chain polymeric drug precursor and its application | 江苏豪森药业集团有限公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-101605539-B | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin | ENZON PHARMACEUTICALS INC US | 2013-01-02 | — | — | CN | disclosed |
| CN-101420963-B | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers | ENZON PHARMACEUTICALS INC | 2012-09-05 | — | — | CN | disclosed |
| CN-102481364-A | Methods of treating HER2 positive cancers with HER2 receptor antagonists in combination with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin | ENZON PHARMACEUTICALS INC | 2012-05-30 | — | — | CN | disclosed |
| CN-101605539-A | Multi-arm polymeric conjugate treatment repellence or refractory cancers with 7-ethyl-10-hydroxycamptothecine | ENZON PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | disclosed |
| CN-101420963-A | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers | ENZON PHARMACEUTICALS INC (US) | 2009-04-29 | — | — | CN | disclosed |
| WO-2009017874-A9 | NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF | UNIV ROCHESTER (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009023357-A2 | CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS | UNIVERSITY OF ROCHESTER (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009017874-A2 | NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMACEUTICAL USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2009-02-05 | — | — | WO | disclosed |