Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | CDC7 | O00311 | 4/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020333 | 0.94 | CDC7 (0.53) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL1447222 | 0.94 | CDK2 (0.53) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL4243889 | 0.91 | MAPK14 (0.47) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL4029553 | 0.86 | MAPK14 (0.43) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL6105497 | 0.78 | CDK2 (0.51) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL4030274 | 0.78 | CDK2 (0.54) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL4031036 | 0.77 | CDK2 (0.45) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL1448411 | 0.76 | CDK2 (0.50) | CDK2CDC7DYRK3CCNT1CDK9 | |
| SCHEMBL4025419 | 0.75 | CDK2 (0.64) | CDK2CCNT1CDK9CDK4CCNE1 | |
| SCHEMBL278830 | 0.75 | CDK2 (0.56) | CDK2CDC7DYRK3CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |