Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 5/20 | 0.43 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265947 | 1.00 | EPHX1 (0.46) | EPHX1PLA2G10PLA2G2ACCR1SRR | |
| SCHEMBL4180733 | 0.94 | EPHX1 (0.51) | EPHX1PLA2G10PLA2G2ACCR1SRR | |
| SCHEMBL27832973 | 0.83 | CPN1 (0.45) | EPHX1PLA2G10PLA2G2ACCR1ALPI | |
| SCHEMBL22610143 | 0.81 | MFN2 (0.43) | EPHX1LMNATDP1 | |
| SCHEMBL22610142 | 0.81 | MFN2 (0.43) | EPHX1LMNATDP1 | |
| SCHEMBL4156782 | 0.78 | EPHX1 (0.43) | EPHX1CCR1ALPIPKMPTGS1 | |
| SCHEMBL4156781 | 0.78 | EPHX1 (0.43) | EPHX1CCR1ALPIPKMPTGS1 | |
| SCHEMBL28164088 | 0.76 | PPARG (0.46) | EPHX1LMNA | |
| SCHEMBL9816105 | 0.76 | KCNA3 (0.41) | EPHX1SRRALPIPKMPTGS1 | |
| SCHEMBL10450048 | 0.76 | CYP1A2 (0.39) | EPHX1SRRALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008034736-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-27 | — | — | WO | disclosed |