Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023506 | 0.88 | PAK1 (0.52) | PAK1P2RX7MAPK14KMT2AMEN1 | |
| SCHEMBL4019812 | 0.83 | PAK1 (0.58) | PAK1P2RX7KMT2AMEN1KDR | |
| SCHEMBL4016122 | 0.82 | PAK1 (0.51) | PAK1P2RX7MAPK14KMT2AMEN1 | |
| SCHEMBL4024040 | 0.81 | PAK1 (0.47) | PAK1P2RX7KMT2AMEN1DRD4 | |
| SCHEMBL4024051 | 0.78 | PAK1 (0.57) | PAK1P2RX7MAPK14KMT2AMEN1 | |
| SCHEMBL4023555 | 0.78 | PAK1 (0.52) | PAK1P2RX7MELKCNR1CNR2 | |
| SCHEMBL4017222 | 0.77 | PAK1 (0.56) | PAK1P2RX7MAPK14KMT2AMEN1 | |
| SCHEMBL4022683 | 0.75 | PAK1 (0.42) | PAK1P2RX7KMT2AMEN1DRD4 | |
| SCHEMBL4017912 | 0.75 | PAK1 (0.46) | PAK1P2RX7KMT2AMEN1DRD4 | |
| SCHEMBL4024515 | 0.73 | PAK1 (0.56) | PAK1P2RX7KMT2AMEN1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |