Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30114438 | 1.00 | TRPV1 (0.64) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL5660097 | 0.88 | TRPV1 (0.71) | TRPV1 | |
| SCHEMBL30600745 | 0.87 | TRPV1 (0.52) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL6630943 | 0.85 | TRPV1 (0.59) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL2315592 | 0.85 | KDM4E (0.67) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL4023574 | 0.85 | MAPT (0.62) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL30544195 | 0.85 | KDM4E (0.67) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL17737359 | 0.84 | KMT2A (0.76) | TRPV1KMT2AMEN1MAPK1HTT | |
| Hydrochloric Acid SCHEMBL2319974 | 0.84 | KDM4E (0.65) | TRPV1KMT2AMEN1MAPK1HTT | |
| SCHEMBL13151501 | 0.83 | TRPV1 (0.73) | TRPV1KMT2AMEN1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| CN-116096372-A | EGFR inhibitor, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-106661018-B | Pyrrolo- [2,3-C] pyridine as neurofibrillary tangles imaging agent | 默沙东公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-106661018-A | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles | 默沙东公司 | 2017-05-10 | — | — | CN | disclosed |