SCHEMBL4023795

SCHEMBL4023795

COCNC(=O)c1cc(C(=O)NCc2ccc(S(=O)(=O)C(C)C)cc2)c(=O)n(-c2cccc(C(F)(F)F)c2)c1C

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 19/20 0.59
CCR1 P32246 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4019713 0.90 ELANE (0.62) ELANE
SCHEMBL29875716 0.90 ELANE (0.62) ELANE
SCHEMBL4021644 0.88 ELANE (0.63) ELANE
SCHEMBL4022876 0.88 ELANE (0.63) ELANE
SCHEMBL4158289 0.87 ELANE (0.62) ELANE
SCHEMBL4025177 0.86 ELANE (0.61) ELANE
SCHEMBL4161096 0.85 ELANE (0.61) ELANE
SCHEMBL4022883 0.85 ELANE (0.58) ELANE
SCHEMBL29808738 0.85 ELANE (0.58) ELANE
SCHEMBL16897392 0.85 ELANE (0.60) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1663974-B1 2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2009-01-14 EP disclosed