SCHEMBL4024431

SCHEMBL4024431

CCCCN[C@@H](Cc1ccccc1)C(=O)OC

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.63
TSHR P16473 1/20 0.55
BCHE P06276 1/20 0.55
ATM Q13315 1/20 0.55
BIRC2 Q13490 1/20 0.54
ALDH1A1 P00352 2/20 0.53
THRB P10828 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HSD17B10 Q99714 1/20 0.53
GAA P10253 1/20 0.51
RAB9A P51151 1/20 0.51
HDAC1 Q13547 4/20 0.50
HDAC6 Q9UBN7 4/20 0.50
CA12 O43570 1/20 0.50
CA2 P00918 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
LMNA P02545 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9008918 0.99 POLB (0.61) POLBTSHRBCHEATMBIRC2
Hydrochloric Acid SCHEMBL9008916 0.99 POLB (0.61) POLBTSHRBCHEATMBIRC2
SCHEMBL9491800 0.96 POLB (0.61) POLBTSHRBCHEATMBIRC2
SCHEMBL9490405 0.96 POLB (0.61) POLBTSHRBCHEATMBIRC2
SCHEMBL9487005 0.96 POLB (0.61) POLBTSHRBCHEATMBIRC2
SCHEMBL28885763 0.94 POLB (0.60) POLBTSHRBCHEATMBIRC2
SCHEMBL28953193 0.94 POLB (0.60) POLBTSHRBCHEATMBIRC2
SCHEMBL25590532 0.94 POLB (0.60) POLBTSHRBCHEATMBIRC2
SCHEMBL12197317 0.92 POLB (0.59) POLBTSHRATMALDH1A1THRB
SCHEMBL12197316 0.91 POLB (0.58) POLBTSHRATMALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1689713-A4 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE MERCK & CO INC (US) 2009-02-18 EP disclosed
EP-1689713-A1 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE Merck & Co., Inc. (US) 2006-08-16 EP disclosed
WO-2005051914-A1 BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE MERCK & CO., INC. (US) 2005-06-09 WO disclosed