Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536433 | 0.87 | MAPK14 (0.50) | SYKMAPK14KDRRAF1FGFR1 | |
| SCHEMBL3534444 | 0.86 | MAPK14 (0.48) | SYKMAPK14PSEN1PSEN2APH1B | |
| SCHEMBL3531198 | 0.86 | MAPK14 (0.51) | SYKMAPK14FGFR1WEE1SRC | |
| SCHEMBL3536822 | 0.86 | MAPK14 (0.69) | MAPK14KDRRAF1PDGFRAMAPK13 | |
| SCHEMBL3820449 | 0.83 | MAPK14 (0.66) | MAPK14KDRRAF1PDGFRAMAPK13 | |
| SCHEMBL3827651 | 0.83 | MAPK14 (0.47) | SYKMAPK14KDRRAF1FGFR1 | |
| SCHEMBL4024442 | 0.82 | MAPK14 (0.48) | SYKMAPK14RAF1FGFR1WEE1 | |
| SCHEMBL5063013 | 0.81 | SYK (0.45) | SYKMAPK14POLBTHRBKDR | |
| SCHEMBL4420333 | 0.81 | MAPK14 (0.46) | SYKMAPK14RAF1BRAFMAPK13 | |
| SCHEMBL4552696 | 0.80 | FLT3 (0.46) | SYKMAPK14NPC1RAB9APDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094698-A1 | SUBSTITUTED 6-PHENYL-PYRIDO [2,3-D]PYRIMIDIN-7-ONE DERIVATIVES AS KINASE INHIBITORS AND METHODS FOR USING THE SAME | F. Hoffmann-Roche AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008055842-A1 | SUBSTITUTED 6-PHENYL-PYRIDO [2,3-D] PYRIMIDIN-7-ONE DERIVATIVES AS KINASE INHIBITORS AND METHODS FOR USING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |