Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.66 |
| ▸ | MTOR | P42345 | 12/20 | 0.66 |
| ▸ | ATR | Q13535 | 4/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483289 | 0.91 | PIK3CA (0.59) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL8003310 | 0.89 | PIK3CA (0.62) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL7999982 | 0.88 | PIK3CA (0.56) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL8008797 | 0.87 | PIK3CA (0.55) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL8008913 | 0.85 | PIK3CA (0.59) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL8010505 | 0.85 | PIK3CA (0.53) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL8012713 | 0.84 | PIK3CA (0.57) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL1309409 | 0.84 | PIK3CA (0.70) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL4023502 | 0.83 | PIK3CA (0.56) | PIK3CAMTORATRPRKDCPIK3R1 | |
| SCHEMBL4455822 | 0.83 | PIK3CA (0.56) | PIK3CAMTORATRPRKDCPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093981-A1 | TRIAZINE COMPOUNDS AS KINASE INHIBITORS | S BIO PTE LTD (SG) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009093981-A1 | TRIAZINE COMPOUNDS AS KINASE INHIBITORS | S BIO PTE LTD (SG) | 2009-07-30 | — | — | WO | disclosed |