Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 16/20 | 0.82 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.60 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL847897 | 0.91 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL12987681 | 0.86 | MAPK8 (0.62) | MAPK8MAPK9MAPK10FEN1 | |
| SCHEMBL12983814 | 0.79 | MAPK8 (0.78) | MAPK8MAPK9MAPK10 | |
| SCHEMBL13171924 | 0.78 | MAPK8 (0.79) | MAPK8MAPK9MAPK10 | |
| SCHEMBL16530156 | 0.77 | MAPK8 (0.70) | MAPK8MAPK9MAPK10 | |
| SCHEMBL860430 | 0.76 | MAPK8 (0.81) | MAPK8MAPK9MAPK10 | |
| SCHEMBL27800315 | 0.76 | MAPK8 (0.52) | MAPK8MAPK9MAPK10PTGDR2 | |
| SCHEMBL2412937 | 0.75 | MAPK8 (0.57) | MAPK8MAPK9MAPK10PTGDR2PDE4A | |
| SCHEMBL879581 | 0.75 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL848657 | 0.75 | MAPK8 (0.75) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |