Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.66 |
| ▸ | KDR | P35968 | 16/20 | 0.66 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | YES1 | P07947 | 2/20 | 0.52 |
| ▸ | CSK | P41240 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021115 | 0.90 | SRC (0.66) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4026632 | 0.87 | SRC (0.65) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4028427 | 0.86 | SRC (0.61) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4024957 | 0.86 | SRC (0.73) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4021818 | 0.85 | SRC (0.62) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4027114 | 0.84 | SRC (0.67) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4025884 | 0.84 | SRC (0.57) | SRCKDREGFR | |
| SCHEMBL3672594 | 0.84 | SRC (0.75) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4023023 | 0.84 | SRC (0.59) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4024497 | 0.82 | SRC (0.70) | SRCKDREGFRLCKCSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-B1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| EP-1528925-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004004732-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |