Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.84 |
| ▸ | CDK2 | P24941 | 20/20 | 0.84 |
| ▸ | CCNE2 | O96020 | 19/20 | 0.84 |
| ▸ | CDK4 | P11802 | 15/20 | 0.84 |
| ▸ | CCND1 | P24385 | 15/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027313 | 0.94 | CCNE1 (0.73) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4026340 | 0.92 | CCNE2 (1.00) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4025030 | 0.91 | CCNE1 (0.91) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4025433 | 0.90 | CCNE1 (0.81) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4024723 | 0.90 | CCNE1 (0.81) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4026509 | 0.90 | CCNE1 (0.81) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4025029 | 0.87 | CCNE1 (0.85) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4025555 | 0.87 | CCNE1 (0.84) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL4028783 | 0.87 | CCNE1 (1.00) | CCNE1CDK2CCNE2CDK4CCND1 | |
| SCHEMBL7654032 | 0.85 | CCNE1 (0.75) | CCNE1CDK2CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071668-B1 | 5-AMINOINDENO[1,2-C]PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-06-03 | — | — | EP | claimed |
| EP-1071668-B1 | 5-AMINOINDENO[1,2-C]PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-06-03 | — | — | EP | disclosed |
| US-7250435-B2 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-07-31 | — | — | US | disclosed |
| US-20050261353-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-11-24 | — | — | US | disclosed |
| US-20040048844-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-11 | — | — | US | disclosed |
| US-6593356-B2 | The present invention relates to the synthesis of a new class of indeno(1,2-c)pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and the | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-07-15 | — | — | US | disclosed |
| US-20030073686-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-17 | — | — | US | disclosed |
| US-6413957-B1 | CYCLIN DEPENDANT KINASES INHIBITORS; CONTROLLING CELL GROWTH AND DIFFERENTIATION; CANCER, PSORIASIS, LEUKOCYTE IMMUNO-LOGICAL DISORDERS, RESTINOSIS AND OTHER SMOOTH MUSCLE CELL DISORDERS | BRISTOL-MYERS SUIBB PHARMA COMPANY | 2002-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073686-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | CDK1, CCNA1, CDK17 | CCNE1 33/4885CDK2 9/4885CCNE2 48/4885 |
| US-20050261353-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | CDK1, CDK17, CDK7 | CCNE1 41/4885CDK2 6/4885CCNE2 50/4885 |
| US-20040048844-A1 | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents | CDK1, CCNA1, CDK17 | CCNE1 33/4885CDK2 9/4885CCNE2 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.