SCHEMBL4028482

SCHEMBL4028482

CC(C)C(O)(c1ccc2c(ccc3occc32)c1)c1c[nH]cn1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 16/20 0.37
CYP2C8 P10632 1/20 0.37
CYP3A4 P08684 12/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5753882 0.78 CYP3A4 (0.44) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL1415155 0.77 CYP17A1 (0.42) CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19
SCHEMBL5751835 0.77 CYP3A4 (0.44) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL5752256 0.77 CYP3A4 (0.44) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL5678315 0.76 CYP3A4 (0.47) CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19
SCHEMBL5752861 0.76 CYP3A4 (0.47) CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19
SCHEMBL4027830 0.76 CYP17A1 (0.41) CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19
SCHEMBL5749713 0.76 CYP3A4 (0.43) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL5750907 0.76 CYP3A4 (0.44) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL5752772 0.76 CYP3A4 (0.43) CYP17A1CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1222174-B1 IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE TAKEDA PHARMACEUTICAL (JP) 2009-05-27 EP disclosed
US-6649643-B1 Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-11-18 US disclosed
EP-1222174-A1 IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE Takeda Chemical Industries, Ltd. (JP) 2002-07-17 EP disclosed
WO-2001030762-A1 IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-03 WO disclosed