SCHEMBL4028656

SCHEMBL4028656

Cc1c(C(N)=O)ccc2cc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)ccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 10/20 0.42
CYP3A4 P08684 7/20 0.35
SIRT2 Q8IXJ6 6/20 0.35
RORC P51449 1/20 0.33
CYP2C8 P10632 1/20 0.31
JAK2 O60674 1/20 0.30
NTRK1 P04629 1/20 0.30
LCK P06239 1/20 0.30
LYN P07948 1/20 0.30
RET P07949 1/20 0.30
SRC P12931 1/20 0.30
TEC P42680 1/20 0.30
TXK P42681 1/20 0.30
BLK P51451 1/20 0.30
BMX P51813 1/20 0.30
BTK Q06187 1/20 0.30
ITK Q08881 1/20 0.30
KCNH2 Q12809 1/20 0.30
ERBB4 Q15303 1/20 0.30
NTRK2 Q16620 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4034127 0.90 CYP17A1 (0.43) CYP17A1CYP3A4SIRT2RORCCYP2C8
SCHEMBL4029531 0.89 CYP17A1 (0.56) CYP17A1CYP3A4SIRT2RORC
SCHEMBL1414878 0.89 CYP17A1 (0.43) CYP17A1CYP3A4SIRT2
SCHEMBL4025489 0.86 CYP3A4 (0.42) CYP17A1CYP3A4SIRT2
SCHEMBL1414859 0.86 CYP17A1 (0.36) CYP17A1CYP3A4SIRT2RORCCYP2C8
SCHEMBL4026083 0.84 CYP17A1 (0.44) CYP17A1CYP3A4SIRT2RORCCYP2C8
SCHEMBL314181 0.84 SIRT2 (0.32) CYP17A1SIRT2
SCHEMBL4027110 0.84 CYP3A4 (0.51) CYP17A1CYP3A4SIRT2
SCHEMBL4027150 0.81 CYP17A1 (0.44) CYP17A1CYP3A4SIRT2RORC
SCHEMBL7266948 0.81 CYP17A1 (0.56) CYP17A1CYP3A4SIRT2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1222174-B1 IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE TAKEDA PHARMACEUTICAL (JP) 2009-05-27 EP disclosed
US-6649643-B1 Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-11-18 US disclosed
EP-1222174-A1 IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE Takeda Chemical Industries, Ltd. (JP) 2002-07-17 EP disclosed
WO-2001030762-A1 IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-03 WO disclosed