Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 15/20 | 0.79 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026174 | 0.88 | SCARB1 (1.00) | SCARB1HSD17B10 | |
| SCHEMBL4029779 | 0.86 | SCARB1 (0.82) | SCARB1HSD17B10 | |
| SCHEMBL13746702 | 0.86 | SCARB1 (0.81) | SCARB1HSD17B10NPC1 | |
| SCHEMBL13746499 | 0.83 | SCARB1 (0.77) | SCARB1 | |
| SCHEMBL4193427 | 0.79 | SCARB1 (0.81) | SCARB1HSD17B10 | |
| SCHEMBL4205318 | 0.79 | SCARB1 (0.73) | SCARB1 | |
| SCHEMBL4200388 | 0.79 | SCARB1 (0.73) | SCARB1 | |
| SCHEMBL13746552 | 0.78 | SCARB1 (0.71) | SCARB1 | |
| SCHEMBL4727932 | 0.78 | SCARB1 (0.54) | SCARB1RORCTP53NPC1RAB9A | |
| SCHEMBL4033003 | 0.78 | SCARB1 (0.80) | SCARB1HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |