Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029413 | 0.92 | EGFR (0.79) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL5472240 | 0.92 | EGFR (0.78) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4029962 | 0.89 | EGFR (0.64) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4028921 | 0.89 | EGFR (0.66) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL5474458 | 0.88 | EGFR (0.64) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4028325 | 0.88 | ERBB2 (0.70) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL5478352 | 0.88 | EGFR (0.65) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4034109 | 0.88 | EGFR (0.74) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4031625 | 0.87 | EGFR (0.80) | EGFRERBB2KCNH2SRC | |
| Hydrochloric Acid SCHEMBL4030699 | 0.86 | ERBB2 (0.60) | EGFRERBB2KCNH2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444210-B1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| US-20070082921-A1 | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB | 2007-04-12 | — | — | US | disclosed |
| US-20050043336-A1 | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | US | disclosed |
| EP-1458703-A1 | ISOCHROMAN COMPOUNDS FOR TREATMENT OF CNS DISORDERS | ELI LILLY AND COMPANY (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-1444210-A1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003053948-A1 | ISOCHROMAN COMPOUNDS FOR TREATMENT OF CNS DISORDERS | ELI LILLY AND COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003040108-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043336-A1 | Quinazoline derivatives as antitumor agents | ERBB2, ERBB3, ABL1 | EGFR 4/4885ERBB2 1/4885KCNH2 1510/4885 |
| US-20070082921-A1 | Quinazoline derivatives as antitumor agents | ERBB2, EGFR, ERBB4 | EGFR 2/4885ERBB2 1/4885KCNH2 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.