Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 4/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031036 | 0.81 | CDK2 (0.45) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL5102065 | 0.73 | CCNT1 (0.44) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL5258483 | 0.72 | CDC7 (0.46) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL4024077 | 0.72 | CDK2 (0.46) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL4248467 | 0.70 | CDK2 (0.54) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL5109492 | 0.69 | CDK2 (0.72) | CDK2CCNT1CDK9CDK4CCNA2 | |
| SCHEMBL1447807 | 0.68 | MAPK14 (0.42) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL5102072 | 0.68 | MAPK14 (0.37) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL278830 | 0.68 | CDK2 (0.56) | CDK2DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL4022085 | 0.66 | CDC7 (0.51) | CDK2DYRK3CCNT1CDK9DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |