Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034173 | 0.69 | ESR1 (0.45) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL4028546 | 0.63 | ESR1 (0.47) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL3659579 | 0.62 | RXRB (0.60) | DHODHMCL1POLBHSD17B10L3MBTL1 | |
| SCHEMBL10024268 | 0.62 | MCL1 (0.61) | DHODHMCL1HSD17B10KDM4E | |
| SCHEMBL15317984 | 0.62 | CYP1A2 (0.65) | MCL1HSD17B10KDM4EMYC | |
| SCHEMBL15317983 | 0.62 | CYP1A2 (0.65) | MCL1HSD17B10KDM4EMYC | |
| SCHEMBL27747520 | 0.62 | MCL1 (0.44) | DHODHMCL1POLBHSD17B10KDM4E | |
| SCHEMBL30503372 | 0.61 | KDM4E (0.45) | KDM4EKDM6BKDM6ATET3KDM4A | |
| SCHEMBL20850515 | 0.60 | CYP1A2 (0.70) | MCL1HSD17B10KDM4EMYC | |
| SCHEMBL14186130 | 0.60 | CYP1A2 (0.70) | MCL1HSD17B10KDM4EMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | claimed |