SCHEMBL4030462

SCHEMBL4030462

CC[Si](CC)(CC)O[C@H]1C(=O)N[C@H]1C(C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4030467 1.00
SCHEMBL7087266 1.00
SCHEMBL6331383 0.71
SCHEMBL6783809 0.71
SCHEMBL6331381 0.71
SCHEMBL7466364 0.68
SCHEMBL6332675 0.67 MEN1 (0.41)
SCHEMBL4058003 0.67 POLB (0.35)
SCHEMBL4055843 0.67 POLB (0.35)
SCHEMBL4175106 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272193-B1 SYNERGISTIC COMBINATION THERAPY FOR TREATING CANCER BRISTOL MYERS SQUIBB CO (US) 2009-05-06 EP disclosed
EP-1372636-B1 METRONOMIC DOSING OF TAXANES FOR INHIBITING TUMOR GROWTH BRISTOL MYERS SQUIBB CO (US) 2006-06-28 EP disclosed
EP-1623706-A2 Metronomic dosing of taxanes for inhibiting tumor growth BRISTOL-MYERS SQUIBB COMPANY (US) 2006-02-08 EP disclosed
US-20050250844-A1 Methods of treating cancer using C-4 carbonate taxanes BRISTOL-MYERS SQUIBB COMPANY 2005-11-10 US disclosed
US-6916942-B2 Process for the preparation of C-4 carbonate taxanes BRISTOL-MYERS SQUIBB COMPANY (US) 2005-07-12 US disclosed
US-20040225009-A1 Process for the preparation of C-4 carbonate taxanes BRISTOL-MYERS SQUIBB COMPANY 2004-11-11 US disclosed
EP-1251846-B1 C-4 CARBONATE TAXANES BRISTOL MYERS SQUIBB CO (US) 2004-08-11 EP disclosed
US-20040143004-A1 Metronomic dosing of taxanes CERAM TEC AG, INNOVATIVE CERAMIC ENGINEERING (DE) 2004-07-22 US disclosed
US-6750246-B1 NOVEL ORALLY ACTIVE PACLITAXEL DERIVATIVES BRISTOL-MYERS SQUIBB COMPANY 2004-06-15 US disclosed
US-6537988-B2 Imidazole-1h-1,4-benzodiazepine derivatives along with antiproliferative cytotoxic and cytostatic agents BRISTOL-MYERS SQUIBB COMPANY 2003-03-25 US disclosed
EP-1251846-A4 C-4 CARBONATE TAXANES BRISTOL MYERS SQUIBB CO (US) 2003-03-12 EP disclosed
EP-1272193-A2 SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER Bristol-Myers Squibb Company (US) 2003-01-08 EP disclosed
EP-1251846-A1 C-4 CARBONATE TAXANES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-30 EP disclosed
US-20020002162-A1 Synergistic methods and compositions for treating cancer BRISTOL-MYERS SQUIBB COMPANY 2002-01-03 US disclosed
WO-2001072721-A2 SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER BRISTOL-MYERS SQUIBB COMPANY (US) 2001-10-04 WO disclosed
WO-2001056565-A1 C-4 CARBONATE TAXANES BRISTOL-MYERS SQUIBB COMPANY (US) 2001-08-09 WO disclosed