SCHEMBL4030749

SCHEMBL4030749

C=CCc1c(OC(C)(C)C(=O)O)ccc2c(CCc3sc(-c4ccccc4C(F)(F)F)nc3C(C)C)noc12

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 19/20 0.54
PPARG P37231 18/20 0.54
PPARD Q03181 17/20 0.54
NR1H4 Q96RI1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4030682 0.93 PPARA (0.46) PPARAPPARGPPARD
SCHEMBL4030747 0.87 PPARA (0.69) PPARAPPARGPPARD
SCHEMBL4025440 0.83 PPARA (0.77) PPARAPPARGPPARD
SCHEMBL4030679 0.81 PPARA (0.60) PPARAPPARGPPARD
SCHEMBL4028134 0.78 PPARG (0.40) PPARAPPARGPPARD
SCHEMBL4034554 0.75 PPARD (0.65) PPARAPPARGPPARD
SCHEMBL4034274 0.74 PPARG (0.52) PPARAPPARGPPARDNR1H4
SCHEMBL2464201 0.73 PPARD (0.49) PPARAPPARGPPARD
SCHEMBL2464495 0.73 PPARA (0.46) PPARAPPARGPPARD
SCHEMBL3393036 0.72 PPARD (0.62) PPARAPPARGPPARDNR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US claimed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP claimed
US-20190255022-A1 WOUND-HEALING AGENT NIPPON CHEMIPHAR CO., LTD. (JP) 2019-08-22 US disclosed
EP-3456327-A1 WOUND-HEALING AGENT Nippon Chemiphar Co., Ltd. (JP) 2019-03-20 EP disclosed
EP-1445258-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO (JP) 2009-06-24 EP disclosed
US-7402597-B2 Activator of peroxisome proliferator-activated receptor δ NIPPON CHEMIPHAR CO., LTD (JP) 2008-07-22 US disclosed
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta SAKUMA SHOGO 2007-02-01 US disclosed
US-7119104-B2 Activator of peroxisome proliferator-activated receptor delta NIPPON CHEMIPHAR, CO., LTD. (JP) 2006-10-10 US disclosed
US-20050096363-A1 Activator of peroxisome proliferator-activated receptor delta NIPPON CHEMIPHAR CO., LTD. (JP) 2005-05-05 US disclosed
EP-1445258-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA NIPPON CHEMIPHAR CO., LTD. (JP) 2004-08-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255022-A1 WOUND-HEALING AGENT PPARG, PPARA, PPARD PPARA 2/4885PPARG 1/4885PPARD 3/4885
US-20070027196-A1 Activator of peroxisome proliferator-activated receptor delta PPARA, PPARG, PPARD PPARA 1/4885PPARG 2/4885PPARD 3/4885
US-20050096363-A1 Activator of peroxisome proliferator-activated receptor delta PPARA, PPARG, PPARD PPARA 1/4885PPARG 2/4885PPARD 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.