Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 9/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5414144 | 0.84 | ESR1 (0.52) | ESR1BTKEGFRCMKLR1MEN1 | |
| SCHEMBL4030883 | 0.72 | ESR1 (0.68) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4025902 | 0.72 | ESR1 (0.65) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL8134821 | 0.72 | AKT1 (0.43) | MEN1KMT2A | |
| SCHEMBL4031427 | 0.71 | ESR1 (0.65) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4030592 | 0.69 | ESR1 (0.69) | ESR1BTKCMKLR1 | |
| SCHEMBL4025780 | 0.69 | ESR1 (0.97) | ESR1BTKEGFRCMKLR1MERTK | |
| SCHEMBL4028914 | 0.68 | ESR1 (0.60) | ESR1BTKEGFRCMKLR1MERTK | |
| SCHEMBL4027934 | 0.65 | ESR1 (0.51) | ESR1BTKEGFRCMKLR1 | |
| SCHEMBL4032206 | 0.64 | ESR1 (0.62) | ESR1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | claimed |