Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 14/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.54 |
| ▸ | CDK2 | P24941 | 14/20 | 0.54 |
| ▸ | CDK4 | P11802 | 13/20 | 0.52 |
| ▸ | CCND1 | P24385 | 13/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023974 | 0.83 | CCNE1 (0.79) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4023996 | 0.76 | CCNE1 (0.92) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4028776 | 0.75 | CCNE1 (0.87) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL5521970 | 0.72 | CCNE2 (0.79) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL14452737 | 0.72 | CDK4 (0.82) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4025026 | 0.70 | CCNE1 (0.79) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL5515366 | 0.69 | CCNE2 (0.82) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4023836 | 0.69 | CCNE2 (0.85) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4025252 | 0.69 | CCNE2 (0.68) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4028783 | 0.68 | CCNE1 (1.00) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071668-B1 | 5-AMINOINDENO[1,2-C]PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-06-03 | — | — | EP | claimed |