SCHEMBL4031135 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK14	Q16539	9/20	0.51

▸	MAPK11	Q15759	5/20	0.51

▸	MAPK13	O15264	4/20	0.51

▸	MAPK12	P53778	4/20	0.51

▸	MAPK9	P45984	3/20	0.51

▸	RAF1	P04049	1/20	0.51

▸	BTK	Q06187	2/20	0.38

▸	PTGES	O14684	2/20	0.37

▸	F2R	P25116	1/20	0.35

▸	CPT2	P23786	1/20	0.35

▸	CPT1A	P50416	1/20	0.35

▸	MCHR1	Q99705	1/20	0.35

▸	TRPV4	Q9HBA0	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4035352	0.92	MAPK14 (0.42)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL8011517	0.90	MAPK14 (0.52)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4025102	0.90	MAPK14 (0.52)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4025055	0.89	MAPK14 (0.69)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4027551	0.84	MAPK14 (0.41)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4025897	0.83	MAPK14 (0.51)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL8604095	0.82	BTK (0.47)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL8603751	0.82	BTK (0.47)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4027239	0.81	MAPK14 (0.43)	MAPK14MAPK11MAPK13MAPK12MAPK9
SCHEMBL4029885	0.79	MAPK14 (0.71)	MAPK14MAPK11MAPK13MAPK12MAPK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0854870-B1	SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY	MERCK & CO INC (US)	2009-06-10	—	—	EP	claimed