Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.75 |
| ▸ | ABL1 | P00519 | 4/20 | 0.57 |
| ▸ | BCR | P11274 | 3/20 | 0.57 |
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 7/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | FES | P07332 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918897 | 0.86 | AURKA (1.00) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL4031393 | 0.84 | AURKA (0.53) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2919281 | 0.78 | CDK2 (0.81) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2915930 | 0.77 | AURKA (0.80) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2917581 | 0.77 | AURKA (1.00) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2916018 | 0.74 | AURKA (0.69) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2917423 | 0.74 | CCNA2 (0.72) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2923322 | 0.73 | AURKA (1.00) | AURKAABL1BCRPLK1CDK2 | |
| SCHEMBL2921962 | 0.71 | CDK2 (1.00) | AURKACDK2CCNA2CCNA1CDK1 | |
| SCHEMBL2916455 | 0.71 | CCNA2 (0.55) | AURKACDK2CCNA2CCNA1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531531-B2 | Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles | PFIZER ITALIA S.R.L. (IT) | 2009-05-12 | — | — | US | disclosed |
| US-20070191386-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191386-A1 | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K19, MAP3K1 | AURKA 347/4885ABL1 367/4885BCR 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.